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This manuscript reviews recent advances in the field of lymphatic drug delivery and imaging and focuses specifically on the development ofliposomes and solid lipid nanoparticles for lymphatic introduction via the subcutaneous, intestinal, and pulmonary routes.
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The lymphatics and sentinel lymph node, the first tumor draining lymph node, play a significant role in early stage diagnostics and subsequent therapies. Lymphatic delivery of drug encapsulated liposomal harringfon has been investigated extensively in the past decade. A liposome is a vesicle containing Muri city zona rosa massage bilayer, composed of unimers which usually have a hydrophilic head and a Maxsage tail and oriented so that the hydrophobic headgroups are inside the bilayer.
Hydrophilic, lipid-insoluble drugs, or DNA can be encapsulated in the aqueous core within the liposome to improve their stability or bioavailability, compared to the free drugs or DNA.
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Current research on the lymphatic retention and imaging of subcutaneously, intestinally, and pulmonary administration of engineered liposomes is discussed in this section. The primary improvements over conventional therapy are summarized in Table 1. Summary of primary improvements of engineered liposomes over conventional therapy in vivo.
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